Helper-Dependent Adenoviral Vector-Mediated Delivery of Woodchuck-Specific Genes for Alpha Interferon (IFN- ) and IFN- : IFN- but Not IFN- Reduces Woodchuck Hepatitis Virus Replication in Chronic Infection In Vivo
نویسندگان
چکیده
10.1128/JVI.78.18.10111-10121.2004. 2004, 78(18):10111. DOI: J. Virol. Brigitte M. Pützer, Fabio Palombo and Michael Roggendorf Lu, Luigi Aurisicchio, Uta Dahmen, Li Jun, Olaf Dirsch, Melanie Fiedler, Florian Rödicker, Valentina Salucci, Mengji Replication in Chronic Infection In Vivo Reduces Woodchuck Hepatitis Virus γ IFNbut Not α : IFNγ ) and IFNα Interferon (IFNWoodchuck-Specific Genes for Alpha Vector-Mediated Delivery of Helper-Dependent Adenoviral
منابع مشابه
IFN-alpha gene therapy for woodchuck hepatitis with adeno-associated virus: differences in duration of gene expression and antiviral activity using intraportal or intramuscular routes.
Gene delivery of IFN-alpha to the liver may represent an interesting strategy to maximize its antiviral efficacy and reduce side effects. We used a recombinant adeno-associated virus (AAV) encoding woodchuck IFN-alpha (AAV-IFN) to treat animals with chronic woodchuck hepatitis virus infection. The vector was given by intraportal or intramuscular route. Long-term transgene expression was detecte...
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